📃 Paper Title: Surgical histopathology for suspected oncocytoma on renal mass biopsy: a systematic review and meta‐analysis
🧍 Author: Patel
🕒 Year: 2017
📚 Journal: BJU International
🌎 Country: USA
ㅤContext to the study:
Can you tell me about the limitations of renal mass biopsy for oncocytoma?
ㅤ✅ Take-home message of study:
Renal mass biopsy (RMB) was found to be unreliable in confidently diagnosing a localised renal mass as an oncocytoma, with one in four found to be RCC on surgical pathology
Patients and surgeons should be aware of this diagnosis uncertainty when considering management plans
ㅤ Systematic review and meta-analysis
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Study participants:
9 articles in final analysis
Studies with core biopsy data allowing surgical histopathological correlation to RMB
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Key study outcomes:
205 RMBs identifying oncocytic renal neoplasms, of which 48 (22.4%) proceeded to surgery + two additional lesions identified
Of the 48 RMB confirmed oncocytic renal neoplasms that proceeded to surgery, the surgical pathology then showed:
oncocytoma (64.6%)
chromophobe RCC (12.5%)
other RCC (12.5%)
hybrid oncocytic/chromophobe tumour (6.3%)
papillary adenomas (4.2%)
**PPV of oncocytoma on RMB was 67% on pooled meta-analysis (95% CI 34-94%) **
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Study Limitations:
High proportion of the studies judged to be at high risk of bias due to missing reference standard evaluations (surgical pathology) for masses showing oncocytic renal neoplasms on RMB
Small sample sizes generally across studies, and retrospective
Lack of consistent centralised genitourinary pathologist review
Significant heterogeneity between studies (I2 = 71.8%, P < 0.01)
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